1,2-Dichloroethane → 5-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide

HRID 606280노트

반응식

HRID 606280 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10][N:9]=[C:8]([C:11]([OH:13])=O)[CH:7]=1.[N:14]1([CH2:19][CH2:20][CH2:21][NH2:22])[CH:18]=[CH:17][N:16]=[CH:15]1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>CN(C=O)C>[N:14]1([CH2:19][CH2:20][CH2:21][NH:22][C:11]([C:8]2[CH:7]=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[O:10][N:9]=2)=[O:13])[CH:18]=[CH:17][N:16]=[CH:15]1

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 787361H-Imidazole-1-propanamineHCID 10909825-(2-Furyl)isoxazole-3-carboxylic acid

생성물 1

HCID 160034475-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide수율 35%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 5-furan-2-yl-isoxazole-3-carboxylic acid (7 mg) and 3-imidazol-1-yl-propyl amine (0.005 mL) in DMF was added 8 mg of HOBt, 9 mg of EDC and 0.014 mL of TEA. After stirring at room temperature for 18 hrs, the reaction solution was concentrated in vacuo. The obtained concentrate was purified by preparative HPLC to afford 4 mg of 5-furan-2-yl-isoxazole-3-carboxylic acid (3-imidazol-1-yl-propyl)-amide (Yield: 35%).

후처리

  1. concentrationthe reaction solution was concentrated in vacuo
  2. concentrationThe obtained concentrate
  3. customwas purified by preparative HPLC

출처 및 근거

ORD 기록
ord-4dea77881e024dff89cffa0247b4acec
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915297B2

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