HCID 178509869, 화합물 → HCID 178509870, 화합물
반응식
[NH:1]1[CH:5]=[N:4][C:3]([S:6][CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=2)[C:13]#[N:14])=[N:2]1>N.CO.[Ni]>[NH:1]1[CH:5]=[N:4][C:3]([S:6][CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH2:13][NH2:14])[CH:15]=[CH:16][CH:17]=2)=[N:2]1참가 물질
4
실험 절차
A solution of 3-{[2-(1H-1,2,4-triazol-3-ylthio)ethyl]oxy}benzonitrile obtained in Reference Example 2 (9.00 g, 36.5 mmol) and Raney-nickel (5.00 g) in 5N ammonia/methanol (300 mL) was stirred at room temperature overnight under hydrogen atmosphere (1 atm). The catalyst was filtered off, and the filtrate was concentrate. The obtained residue was crystallized from toluene to give the title compound as a pale-blue powder (6.45 g, 71%).
후처리
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrate
- customThe obtained residue was crystallized from toluene
출처 및 근거
- ORD 기록
- ord-1d70a8ac2cd844139fb9f697eadfb599
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07915267B2
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