HCID 178470798, 화합물 → HCID 178470784, 화합물

HRID 606447노트

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HRID 606447 반응식
S[C:2]1[NH:6][N:5]=[C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:3]=1>C(O)C.[Ni]>[NH:6]1[CH:2]=[N:3][C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:5]1

참가 물질

4

반응물 1

HCID 178470798HCID 178470798, 화합물

생성물 1

HCID 178470784HCID 178470784, 화합물수율 54%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

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온도
80 °C

실험 절차

A suspension of ethyl (5-mercapto-1H-1,2,4-triazol-3-yl)acetate obtained in Reference Example 13 (2.00 g, 10.7 mmol) and Raney-nickel (5.00 g) in ethanol (20 mL) was stirred at 80° C. for 15 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. To a suspension of the residue in ethyl acetate was added activated carbon, and the mixture was filtered. the filtrate was concentrated under reduced pressure to give the title compound as a pale-green powder (900 mg, 54%).

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. additionTo a suspension of the residue in ethyl acetate
  4. additionwas added
  5. filtrationthe mixture was filtered
  6. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ec6dbe2a7c114de798dddae17acccc3d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915267B2

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