Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Ethynylbenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-[(Trimethylsilyl)ethynyl]benzonitrile | HCID 22570318 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Ethynylbenzonitrile | HCID 12088964 | 92% |
반응 단계
Add potassium carbonate (0.138 g, 1 mmol) to a solution of 3-trimethylsilanylethynylbenzonitrile from PREPARATION 5 (2.0 g, 10.1 mmol) in methanol (50 mL). Stir the mixture at room temperature for 20 min and add a 10% aqueous hydrochloric acid solution (4 mL). Concentrate to a reduced volume, add diethyl ether and water and separate the phases. Wash once the aqueous phase with diethyl ether. Combine the organic phases, dry over sodium sulfate and concentrate to obtain the title compound as a solid (1.17 g, 92%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07915424B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-0eabd544b1254993971a164e6b861429 |
| 출처 메모 | uspto-grants-2011_03 |