Potassium Carbonate → 5-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde oxime hydrochloride

HRID 606878노트

반응식

HRID 606878 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[C:12]([CH:16]=O)[CH:13]=[N:14][CH:15]=2)=[CH:4][CH:3]=1.[ClH:18].[NH2:19][OH:20].C(=O)([O-])[O-].[K+].[K+]>>[ClH:18].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[C:12]([CH:16]=[N:19][OH:20])[CH:13]=[N:14][CH:15]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 860764705-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde

생성물 1

HCID 866224755-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde oxime hydrochloride수율 50.8%

실험 절차

Prepare in a similar manner as described in EXAMPLE 6 using 5-(4-fluorophenylethynyl)-pyridine-3-carbaldehyde (150 mg, 0.64 mmol), (prepared essentially as described in EXAMPLE 99), hydroxylamine hydrochloride (360 mg, 5.15 mmol) and potassium carbonate (440 mg, 3.22 mmol) to give the title compound (90 mg, 50%).

후처리

  1. customPrepare in a similar manner
  2. custom(prepared essentially

출처 및 근거

ORD 기록
ord-d059ff1a646243348ab9c23071fd09c6
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915424B2

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