Potassium Carbonate → 1-(5-Phenylethynyl-pyridin-3-yl)-ethanone oxime hydrochloride

HRID 606930노트

반응식

[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([C:15](=O)[CH3:16])[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:18].[NH2:19][OH:20].C(=O)([O-])[O-].[K+].[K+]>>[ClH:18].[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([C:15](=[N:19][OH:20])[CH3:16])[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 443297Hydroxyamine hydrochloride

HCID 67047758HCID 67047758, 화합물

생성물 1

HCID 866224851-(5-Phenylethynyl-pyridin-3-yl)-ethanone oxime hydrochloride

실험 절차

Prepared in the same manner as described in EXAMPLE 6, using 1-(5-phenylethynyl-pyridin-3-yl)-ethanone, (prepared as described in EXAMPLE 166), (0.22 g, 0.97 mmol), hydroxylamine hydrochloride (0.54 g, 7.78 mmol) and potassium carbonate (0.67 g, 4.86 mmol) to give the free base of the title compound. Convert the free base to the hydrochloride salt as described in EXAMPLE 163 to give the title compound (0.112 g, 42%).

후처리

customPrepared in the same manner

출처 및 근거

ORD 기록: ord-9430417098814bf9ac28402f5ce7b5c1
출처 데이터셋: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07915424B2

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