Acetic Anhydride → HCID 67047834, 화합물
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[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([O:16][CH3:17])[CH:15]=2)=[CH:4][C:3]=1[NH2:18].[C:19](OC(=O)C)(=[O:21])[CH3:20]>N1C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([O:16][CH3:17])[CH:15]=2)=[CH:4][C:3]=1[NH:18][C:19](=[O:21])[CH3:20]참가 물질
4
실험 절차
Dissolve 2-fluoro-5-(5-methoxypyridin-3-ylethynyl)-phenylamine, (prepared as described in EXAMPLE 111), (200 mg, 0.83 mmol) in pyridine (3 mL) and add acetic anhydride (84 mg, 0.83 mmol). Stir under nitrogen at room temperature for 48 h and concentrate. Purify by silica gel chromatography, eluting with 100% ethyl acetate to give the title compound as a light yellow solid (180 mg, 76%).
후처리
- concentrationconcentrate
- customPurify by silica gel chromatography
- washeluting with 100% ethyl acetate
출처 및 근거
- ORD 기록
- ord-ffed0d2626274269a4e9904eb15d5b4e
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07915424B2
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