Dimethylformamide dimethyl acetal → N'-(3-Cyano-6-isopropyl-pyrazin-2-yl)-N,N-dimethyl-formamidine

HRID 607328노트

반응식

HRID 607328 반응식
[NH2:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][CH:5]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:7]=1.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>C1(C)C=CC=CC=1>[C:11]([C:3]1[C:2]([N:1]=[CH:15][N:16]([CH3:18])[CH3:17])=[N:7][C:6]([CH:8]([CH3:10])[CH3:9])=[CH:5][N:4]=1)#[N:12]

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 451224093-Amino-5-isopropylpyrazine-2-carbonitrile

생성물 1

HCID 66808405N'-(3-Cyano-6-isopropyl-pyrazin-2-yl)-N,N-dimethyl-formamidine수율 100.9%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of the product from Example 244B (0.37 g, 2.28 mmol) and dimethylformamide dimethylacetal (0.30 g, 2.5 mmol, 1.1 eq) in toluene (25 mL) was heated under reflux for 1.75 h. The reaction mixture was then cooled to room temperature and the solvent evaporated under reduced pressure to provide the title compound (0.50 g, 100%) as a thick red/brown oil that was used in subsequent reactions without further purification.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 1.75 h
  3. customthe solvent evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-85a837887aca4eb4bebd7c9770ff41fd
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915411B2

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