Dimethylformamide → (S)-5-Oxotetrahydrofuran-2-carbonyl chloride
반응식
[O:1]=[C:2]1[O:6][C@H:5]([C:7]([OH:9])=O)[CH2:4][CH2:3]1.CN(C=O)C.C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl>[O:1]=[C:2]1[O:6][C@H:5]([C:7]([Cl:18])=[O:9])[CH2:4][CH2:3]1참가 물질
5
실험 절차
To a solution of (2S)-5-oxotetrahydrofuran-2-carboxylic acid (compound 28a, 70 g, 539 mmol) and a drop of DMF in anhydrous DCM (500 mL) was added oxalyl dichloride (137 g, 1.07 mol) dropwise. The reaction mixture was stirred at room temperature for 3 hours. The reaction was then concentrated in vacuo to afford 70 g crude product of (2S)-5-oxotetrahydrofuran-2-carbonyl chloride (compound 28b), which was used in next step without further purification.
후처리
- concentrationThe reaction was then concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-77eed8f0a2d446d19676e36e967d82c0
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09441008B2
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