Hydrazine hydrate (1:1) → Methyl 2-fluoro-4-(3-hydrazino-1,2,4-triazin-6-yl)benzoate
반응식
[F:1][C:2]1[CH:11]=[C:10]([C:12]2[N:17]=[N:16][C:15](S(C)=O)=[N:14][CH:13]=2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].O.[NH2:22][NH2:23]>O1CCCC1>[F:1][C:2]1[CH:11]=[C:10]([C:12]2[N:17]=[N:16][C:15]([NH:22][NH2:23])=[N:14][CH:13]=2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]참가 물질
4
실험 절차
To a suspension of methyl 2-fluoro-4-[3-(methylsulfinyl)-1,2,4-triazin-6-yl]benzoate (0.19 g, 0.00064 mol) in tetrahydrofuran (20 mL) was added hydrazine hydrate (63 μL, 0.0013 mol) slowly. The mixture was stirred at RT for 1.5 h. The mixture was concentrated under reduced pressure to yield the desired product. Analytical LCMS: (M+H)+=264.1.
후처리
- concentrationThe mixture was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-88f9e3b4b90946f0a4e935d53a443c80
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07915408B2
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