Chloroacetone → tert-butyl [(1R)-1-(4-methyl-1,3-thiazol-2-yl)ethyl]carbamate

HRID 607617

반응식

HRID 607617 반응식
[NH2:1][C:2](=[S:13])[C@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4].Cl[CH2:15][C:16](=O)[CH3:17]>C(O)C>[CH3:17][C:16]1[N:1]=[C:2]([C@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10])[CH3:4])[S:13][CH:15]=1

참가 물질

4

반응물 2

HCID 6571ChloroacetoneHCID 5324342tert-butyl [(1R)-2-amino-1-methyl-2-thioxoethyl]carbamate

생성물 1

HCID 59216334tert-butyl [(1R)-1-(4-methyl-1,3-thiazol-2-yl)ethyl]carbamate

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of tert-butyl [(1R)-2-amino-1-methyl-2-thioxoethyl]carbamate (100 mg, 0.49 mmol) with 3 equivalents of chloroacetone (0.135 g) in ethanol (1 mL) was heated at 80° C. for 2 h. After cooling, the solution was concentrated. The residue was dissolved in DCM (1 ml). To the solution was added TFA (1 mL). The mixture was stirred at RT for 30 min. The volatiles were removed under reduced pressure to yield desired product.

후처리

  1. temperatureAfter cooling
  2. concentrationthe solution was concentrated
  3. dissolutionThe residue was dissolved in DCM (1 ml)
  4. additionTo the solution was added TFA (1 mL)
  5. customThe volatiles were removed under reduced pressure

출처 및 근거

ORD 기록
ord-4fefd6104feb46b1a8729669818232bf
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915408B2

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