4-Chloroanisole → 4'-Methoxy-2,4,6-trimethylbiphenyl

HRID 607734

반응식

HRID 607734 반응식
COc1ccc(Cl)cc1.Cc1cc(C)c(B(O)O)c(C)c1>C1=C\CC/C=C\CC/1.C1=C\CC/C=C\CC/1.C1COCCO1.COc1ccc(OC)c(P(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Ni]>COc1ccc(-c2c(C)cc(C)cc2C)cc1

참가 물질

8

반응물 2

HCID 121674-ChloroanisoleHCID 2921842,4,6-Trimethylbenzeneboronic acid

생성물 1

HCID 108788734'-Methoxy-2,4,6-trimethylbiphenyl수율 0%

시약·촉매·용매 5

HCID 962Water시약HCID 62657Potassium Phosphate, Tribasic시약HCID 6433264Bis(1,5-cyclooctadiene)nickel촉매HCID 44597232Bis(3,5-bis(trifluoromethyl)phenyl)(3,6-dimethoxy-2',4',6'-tri(propan-2-yl)(1,1'-biphenyl)-2-yl)phosphane촉매HCID 312751,4-Dioxane용매4회

반응 조건

온도
60 °C

실험 절차

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

후처리

  1. additionDilute with acetonitrile
  2. aliquot기록된 절차가 없습니다
  3. customDiluent solution was made in 1 L batches with 950 mL acetonitrile, 25 mL water, 25 mL glacial acetic acid, and 53 mg 4,4’-di-tert-butylbiphenyl as an external standard (0.2 equiv standard per reaction). Aliquot taken from each well (47 ul) is added into 753 ul of diluent solution

출처 및 근거

ORD 기록
ord-3b906e92d75b441284da437f00205d19
출처 데이터셋
Ni-catalyzed Suzuki Miyaura cross-coupling
원본 링크
출처 보기

연결된 노트

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