4-Chloroanisole → Ethyl 4'-methoxy[1,1'-biphenyl]-4-carboxylate

HRID 607850

반응식

HRID 607850 반응식
CCOC(=O)c1ccc(B(O)O)cc1.COc1ccc(Cl)cc1>C1=C\CC/C=C\CC/1.C1=C\CC/C=C\CC/1.C1COCCO1.CCCCCCCCP(CCCCCCCC)CCCCCCCC.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Ni]>CCOC(=O)c1ccc(-c2ccc(OC)cc2)cc1

참가 물질

8

반응물 2

HCID 121674-ChloroanisoleHCID 27343504-Ethoxycarbonylphenylboronic acid

생성물 1

HCID 2764348Ethyl 4'-methoxy[1,1'-biphenyl]-4-carboxylate수율 11%

시약·촉매·용매 5

HCID 962Water시약HCID 62657Potassium Phosphate, Tribasic시약HCID 20851Trioctylphosphine촉매HCID 6433264Bis(1,5-cyclooctadiene)nickel촉매HCID 312751,4-Dioxane용매4회

반응 조건

온도
60 °C

실험 절차

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

후처리

  1. additionDilute with acetonitrile
  2. aliquot기록된 절차가 없습니다
  3. customDiluent solution was made in 1 L batches with 950 mL acetonitrile, 25 mL water, 25 mL glacial acetic acid, and 53 mg 4,4’-di-tert-butylbiphenyl as an external standard (0.2 equiv standard per reaction). Aliquot taken from each well (47 ul) is added into 753 ul of diluent solution

출처 및 근거

ORD 기록
ord-bbcdfb9d292b43eb9dc2178ac2607a59
출처 데이터셋
Ni-catalyzed Suzuki Miyaura cross-coupling
원본 링크
출처 보기

연결된 노트

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