Hydrochloric Acid → 4-(1-(2-allyloxyethyl)-1H-benzimidazole-2-carbonyl)piperidine

HRID 609789노트

반응식

HRID 609789 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([C:16]2[N:20]([CH2:21][CH2:22][O:23][CH2:24][CH:25]=[CH2:26])[C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=3[N:17]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH2:24]([O:23][CH2:22][CH2:21][N:20]1[C:19]2[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=2[N:17]=[C:16]1[C:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15])[CH:25]=[CH2:26]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 183332581-(t-butoxycarbonyl)-4-(1-(2-allyloxyethyl)-1H-benzimidazole-2-carbonyl)piperidine

생성물 1

HCID 183334304-(1-(2-allyloxyethyl)-1H-benzimidazole-2-carbonyl)piperidine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

Combine 1-(t-butoxycarbonyl)-4-(1-(2-allyloxyethyl)-1H-benzimidazole-2-carbonyl)piperidine (1.0 mmol) and dioxane (3 mL). Add a solution of hydrochloric acid in dioxane (4 mL, 4 M, 16 mmol). After 30 minutes, partition the residue between ethyl acetate and saturated aqueous sodium bicarbonate solution. Separate the organic layer and extract with saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give the title compound.

후처리

  1. custompartition the residue between ethyl acetate and saturated aqueous sodium bicarbonate solution
  2. customSeparate the organic layer
  3. extractionextract with saturated aqueous sodium chloride solution
  4. dry with materialDry the organic layer over Na2SO4
  5. filtrationfilter
  6. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-068429cbcadc47338b67d1de1cf23cf0
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998439

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