Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 61025생성일: 2026년 10월 26일
Potassium Carbonate → ((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
https://huagongshe.com/reaction/61025
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Chloro-5-trifluoromethyl-(1,3,4)thiadiazole | HCID 13246789 | — |
| 반응물 | ((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | HCID 89740674 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | ((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | HCID 117727799 | — |
반응 단계
A mixture of ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (0.032 g, 0.1 mmol), 2-chloro-5-(trifluoromethyl)-1,3,4-thiadiazole (0.019 g, 0.1 mmol) and K2CO3 (0.018 g, 0.13 mmol) in DMF was heated at 80° C. overnight. The mixture was purified via preparative-HPLC to obtain the title compound. ESI-MS (m/z): 466 [M+1]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09440982B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-e25ffff606ea4a159a2956e4c7ca8e49 |
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| 출처 메모 | uspto-grants-2016_09 |
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