Ethyl formate → 1,3-Bis(trimethylsilyl)propan-2-ol

HRID 610400노트

반응식

HRID 610400 반응식
C([O:3][CH2:4][CH3:5])=O.[CH3:6][Si:7]([CH2:10][Mg]Cl)([CH3:9])[CH3:8].Cl.[NH4+]>C(OCC)C>[CH3:6][Si:7]([CH3:10])([CH3:9])[CH2:8][CH:4]([OH:3])[CH2:5][Si:7]([CH3:9])([CH3:8])[CH3:6]

참가 물질

5

반응물 3

HCID 8025Ethyl formateHCID 21905121Ammonium hydrochlorideHCID 178418680HCID 178418680, 화합물

생성물 1

HCID 126567131,3-Bis(trimethylsilyl)propan-2-ol수율 70%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Ethyl formate (0.1 mol) was slowly added to 0.3 mol of trimethylsilylmethyl magnesium chloride solution dissolved in diethyl ether which was contained in a 500 ml flask. The mixture was allowed to react under reflux for about 24 hours. After hydrolyzing the reactant using ammonium hydrochloride solution, the obtained reaction product was separated and purified by a vacuum distillation and a 70 percent yield was obtained. The structure of the obtained distillates was analyzed using NMR and a spectroscopic method of FT-IR spectroscopy.

후처리

  1. customwas contained in a 500 ml flask
  2. customto react
  3. temperatureunder reflux for about 24 hours
  4. customthe obtained reaction product
  5. customwas separated
  6. distillationpurified by a vacuum distillation
  7. customa 70 percent yield was obtained

출처 및 근거

ORD 기록
ord-169259283d3540b3b4ec943f1d644776
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998557

반응 노트

불러오는 중…