Anthranilic Acid → Acetanthranil

HRID 610472

반응식

HRID 610472 반응식
[C:1]([OH:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[C:11](OC(=O)C)(=O)[CH3:12]>>[CH3:11][C:12]1[O:9][C:1](=[O:10])[C:2]2[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=2[N:4]=1

참가 물질

3

반응물 2

HCID 227Anthranilic AcidHCID 7918Acetic Anhydride

생성물 1

HCID 68236Acetanthranil

실험 절차

Anthranilic acid (274.3 g) and acetic anhydride (1.1 L) were combined then heated at reflux for 3.5 hours. The reaction mixture was concentrated under vacuum. The residue was combined with methanol (550 mL) then concentrated under vacuum to provide 2-methyl-4-oxo-3,1-benzoxazine as a brown oil.

후처리

  1. temperatureat reflux for 3.5 hours
  2. concentrationThe reaction mixture was concentrated under vacuum
  3. concentrationthen concentrated under vacuum

출처 및 근거

ORD 기록
ord-ffac392fa140465e953adccd91308e75
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998619

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