Hydrochloric Acid → 1-(2-dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-3-(3-phenethylphenyl)propan-1-one hydrochloride

HRID 611101노트

반응식

HRID 611101 반응식
[CH3:1][N:2]([CH2:4][C:5]1[O:31][C:8]2[CH2:9][N:10]([C:13](=[O:30])[CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH:17]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:32]>CO>[ClH:32].[CH3:1][N:2]([CH2:4][C:5]1[O:31][C:8]2[CH2:9][N:10]([C:13](=[O:30])[CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH:17]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 196000521-(2-dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-3-(3-phenethylphenyl)propan-1-one

생성물 1

HCID 196002521-(2-dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-3-(3-phenethylphenyl)propan-1-one hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

1-(2-Dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-3-(3-phenethylphenyl)propan-1-one 0.237 g was dissolved in 2 ml of methanol; hydrogen chloride in methanol was added in excess, followed by stirring. After this mixture was concentrated, diethyl ether was added; the resulting solid was filtered and washed with diethyl ether to yield the desired product.

후처리

  1. concentrationAfter this mixture was concentrated
  2. additiondiethyl ether was added
  3. filtrationthe resulting solid was filtered
  4. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-325af179a641444c9dd1a62838bafa52
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998433

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