Water → 2-Methoxy-6-(trifluoromethyl)benzoic acid

HRID 611720

반응식

HRID 611720 반응식
[CH3:1][O-:2].[K+].F[C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:6]=1[C:7]([OH:9])=[O:8].O>CO>[CH3:1][O:2][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

5

반응물 3

HCID 962WaterHCID 6881232-Fluoro-6-(trifluoromethyl)benzoic acidHCID 23664618Potassium methoxide

생성물 1

HCID 150175332-Methoxy-6-(trifluoromethyl)benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of potassium methylate in methanol (15 ml, 15%) and 2-fluoro-6-trifluoromethylbenzoic acid (2.08 g, 0.01 mol) is heated to reflux with stirring for 40 hours. Upon cooling to room temperature water is added. The reaction mixture is filtered and the filtrate is acidified with concentrated hydrochloric acid. The solid material is collected by filtration, washed with water and dried yielding white crystals, 1.4 g (64%), mp 130-131° C.

후처리

  1. temperatureis heated
  2. temperatureto reflux
  3. additionis added
  4. filtrationThe reaction mixture is filtered
  5. filtrationThe solid material is collected by filtration
  6. washwashed with water
  7. customdried
  8. customyielding white crystals, 1.4 g (64%), mp 130-131° C.

출처 및 근거

ORD 기록
ord-59a931e776544b77ae6ea1b472ab51c4
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06001883

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