EDTA disodium salt → Diclofenac

HRID 612344

반응식

HRID 612344 반응식
[CH:1]1[CH:2]=[CH:3][C:4]([NH:11][C:12]2[C:13]([Cl:19])=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:18])=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1.C([NH2+]CC)C.CC1C(C)=C(OC(CCC(O)=O)=O)C(C)=C2CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)OC=12.C(N(CC([O-])=O)CC(O)=O)CN(CC([O-])=O)CC(O)=O.[Na+].[Na+].CCCCCCCC/C=C\CCCCCCCCOCCO>OCC(CO)O>[CH:1]1[CH:2]=[CH:3][C:4]([NH:11][C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1

참가 물질

6

반응물 4

HCID 8759EDTA disodium saltHCID 20353alpha-Tocopherol succinateHCID 5364713EmulphorHCID 867549572-[2-(2,6-Dichloroanilino)phenyl]acetic acid;diethylazanium

생성물 1

HCID 3033Diclofenac

시약·촉매·용매 1

HCID 753Glycerol용매

실험 절차

A diclofenac submicron cream was prepared as follows: Oil phase--diclofenac diethylammonium 12.2 g, MCT oil 170 g, LIPOID E-80 30 g, α-tocopherol succinate 0.4 g; Aqueous phase--EDTA disodium salt 1 g, EMULFOR EL-620 25 g, glycerol 17.5 g, preservatives (methyl and propyl parabens) 0.5 g, reverse osmosis purified water to 1000 g.

후처리

  1. custompurified water to 1000 g

출처 및 근거

ORD 기록
ord-2d9c142721c249ddbbfea422e455589d
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06004566

연결된 노트

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