Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Isobenzofurandione, 5-(acetyloxy)- → 5-Hydroxy-2-(4-pyridinylamino)isoindole-1,3-dione hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Isobenzofurandione, 5-(acetyloxy)- | HCID 639746 | — |
| 반응물 | 4-Hydrazinylpyridine hydrochloride | HCID 22320258 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 5-Hydroxy-2-(4-pyridinylamino)isoindole-1,3-dione hydrochloride | HCID 19595275 | 56.3% |
반응 단계
A solution of 5-acetoxyphthalic anhydride (3.03 g), 4-hydrazinopyridine hydrochloride (2.04 g) and glacial acetic acid (15 ml) was heated under reflux, under nitrogen, for 4 hrs, with stirring. The reaction mixture was cooled to ambient temperature, the precipitate was collected, washed with water and dried at 60° C. under vacuum overnight. Trituration with hot absolute ethanol gave 2.3 g (56%) of product, mp >260° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06004977 |
| 출처 데이터셋 | uspto-grants-1999_12 |
| ORD ID | ord-0a5be771ed6a4193a0d31ffed8500167 |
| 출처 메모 | uspto-grants-1999_12 |