Water → 6-Bromo-3,4-dimethoxybenzaldehyde

HRID 613029

반응식

HRID 613029 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=[O:7].[Br:13]Br.O>C(O)(=O)C>[Br:13][C:8]1[C:5]([CH:6]=[O:7])=[CH:4][C:3]([O:2][CH3:1])=[C:10]([O:11][CH3:12])[CH:9]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 8419VeratraldehydeHCID 24408Bromine2회

생성물 1

HCID 793516-Bromo-3,4-dimethoxybenzaldehyde

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3,4-Dimethoxybenzaldehyde (398.8 g) is dissolved in acetic acid (1.8 liter), and thereto is added dropwise bromine (136 ml) at room temperature over a period of four hours. The mixture is stirred overnight, and thereto is added dropwise slowly again bromine (60 ml), and the mixture is stirred overnight. The reaction solution is added to water (7 liters), and the precipitated crystals are collected by filtration, washed with water, and dissolved in chloroform (2 liters). The chloroform solution is washed, dried, concentrated, and the residue is crystallized from diisopropyl ether to give 6-bromo-3,4-dimethoxybenzaldehyde (470 g) as a colorless crystal.

후처리

  1. stirringthe mixture is stirred overnight
  2. filtrationthe precipitated crystals are collected by filtration
  3. washwashed with water
  4. dissolutiondissolved in chloroform (2 liters)
  5. washThe chloroform solution is washed
  6. customdried
  7. concentrationconcentrated
  8. customthe residue is crystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-16c7c1bee46443039c28bad0e39a7dec
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06005106

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