Acetic Acid → 3,4-Dimethyl-2-methylenevaleraldehyde

HRID 61326노트

반응식

HRID 61326 반응식
[CH2:1](NCCCC)CCC.C(O)(=O)C.C=O.[CH3:16][CH:17]([CH:21]([CH3:23])[CH3:22])[CH2:18][CH:19]=[O:20]>C1(C)C=CC=CC=1>[CH3:16][CH:17]([CH:21]([CH3:23])[CH3:22])[C:18](=[CH2:1])[CH:19]=[O:20]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 712FormaldehydeHCID 8148DibutylamineHCID 868553,4-Dimethylpentanal

생성물 1

HCID 30204233,4-Dimethyl-2-methylenevaleraldehyde

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
70 °C

실험 절차

Dibutylamine (34 g), acetic acid (15.78 g), and formaldehyde (230 g) were charged to a reaction flask and heated to 70° C. 3,4-Dimethyl-pentanal (500 g) was fed over 2 hours and aged for another hour. The reaction mixture was cooled down and toluene (200 mL) was added. The reaction mixture was sequentially washed with water (2 L), sodium carbonate solution (1 L), and brine (1 L) to provide the crude product 3,4-dimethyl-2-methylene-pentanal.

후처리

  1. waitaged for another hour
  2. temperatureThe reaction mixture was cooled down
  3. washThe reaction mixture was sequentially washed with water (2 L), sodium carbonate solution (1 L), and brine (1 L)

출처 및 근거

ORD 기록
ord-0e1cd97cb31d443f8b2e6efc5a30b738
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09441185B2

반응 노트

불러오는 중…