Hydrochloric Acid → Ethyl 4-hydroxyphenylglycine, hydrochloride

HRID 613364노트

반응식

HRID 613364 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.[ClH:13].[CH3:14][CH2:15]O>>[ClH:13].[CH2:14]([N:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1)[CH2:9][C:10]([OH:12])=[O:11])[CH3:15]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 67149N-(4-Hydroxyphenyl)glycine

생성물 1

HCID 131720465Ethyl 4-hydroxyphenylglycine, hydrochloride수율 70%

실험 절차

To a suspension of 4-hydroxyphenylglycine (18.00 g, 0.11 mol) in EtOH (100 mL) was added 20% ethanolic HCl (30 mL). The mixture was heated at reflux for 14 h, then was allowed to cool and was concentrated under reduced pressure. The residue was partitioned between saturated aqueous NaHCO3 and EtOAc, and the organic extract was concentrated in vacuo to afford the title compound (15.00 g, 70%).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 14 h
  3. temperatureto cool
  4. concentrationwas concentrated under reduced pressure
  5. customThe residue was partitioned between saturated aqueous NaHCO3 and EtOAc
  6. extractionthe organic extract
  7. concentrationwas concentrated in vacuo

출처 및 근거

ORD 기록
ord-83169680b8704fdea48d4c3c0732106c
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008235

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