Dimethyl Sulfoxide → 4-Acetamido-3-methoxybenzaldehyde
반응식
[C:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][OH:10])=[CH:7][C:6]=1[O:13][CH3:14])(=[O:3])[CH3:2].C(N(CC)CC)C.CS(C)=O.ClCCl>O>[C:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][C:6]=1[O:13][CH3:14])(=[O:3])[CH3:2]참가 물질
6
실험 절차
To a mixture of 4-acetamido-3-methoxybenzyl alcohol (800 mg), triethylamine (2.07 g), dimethylsulfoxide (5 ml) and dichloromethane (2.5 ml) was added portionwise sulfur trioxide pyridine complex (1.3 g) in water bath, and the mixture was stirred for 2 hours at the same temperature. The reaction mixture was poured into water, and extracted with dichloromethane. The organic layer was washed with water and brine, dried over magnesium sulfate and concentrated in vacuo to give 4-acetamido-3-methoxybenzaldehyde (653 mg).
후처리
- extractionextracted with dichloromethane
- washThe organic layer was washed with water and brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-dd0bd5bd6f924a87aaf90e16d9644088
- 출처 데이터셋
- uspto-grants-1999_12
- 특허 번호
- US06008229
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