Imidazole → 8-Hydroxy-4-(1H-imidazol-yl)-2-methylquinoline
반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1.C(Cl)(Cl)Cl.C(=O)(O)[O-].[Na+]>O1CCOCC1>[OH:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([CH3:13])[CH:3]=[C:2]2[N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1참가 물질
6
실험 절차
The solution of 4-chloro-8-hydroxy-2-methylquinoline (2.0 g), imidazole (3.52 g) in dioxane (20 ml) was refluxed for 18 hours. The cooled reaction mixture was added chloroform and aqueous sodium bicarbonate solution. The organic layer was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was crystallized from ether to give 8-hydroxy-4-(imidazol-1-yl)-2-methylquinoline (1.99 g) as colorless crystals.
후처리
- customThe cooled reaction mixture
- washThe organic layer was washed with water
- dry with materialdried over magnesium sulfate
- customevaporated in vacuo
- customThe residue was crystallized from ether
출처 및 근거
- ORD 기록
- ord-5853b344900c46549b80e590f516101e
- 출처 데이터셋
- uspto-grants-1999_12
- 특허 번호
- US06008229
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