Pyridine → 8-Acetoxy-2-methylimidazo[1,2-a]pyridine

HRID 613617

반응식

HRID 613617 반응식
[OH:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13].N1C=CC=CC=1>ClCCl>[C:12]([O:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1)(=[O:14])[CH3:13]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 8209532-Methylimidazo[1,2-a]pyridin-8-ol

생성물 1

HCID 183219268-Acetoxy-2-methylimidazo[1,2-a]pyridine수율 102%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 8-hydroxy-2-methylimidazo[1,2-a]pyridine (10 g), acetic anhydride (10.3 g) and pyridine (10.7 g) in anhydrous dichloromethane (100 ml) was stirred for 1 hour at ambient temperature and allowed to stand overnight. The 30 mixture was washed with water, and the organic layer was separated. The aqueous layer was neutralized with sodium bicarbonate and extracted with chloroform. The combined organic layers were washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated in vacuo to give 8-acetoxy-2-methylimidazo[1,2-a]pyridine (13.1 g) as oil.

후처리

  1. waitto stand overnight
  2. washThe 30 mixture was washed with water
  3. customthe organic layer was separated
  4. extractionextracted with chloroform
  5. washThe combined organic layers were washed with saturated sodium bicarbonate solution
  6. dry with materialdried over magnesium sulfate
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-c73c14e2cff948938980e69f1e0397eb
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008229

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