Methylamine → HCID 10643064, 화합물

HRID 613639노트

반응식

HRID 613639 반응식
[Cl:1][C:2]1[C:20](/[CH:21]=[CH:22]/[CH2:23][N:24]2C(=O)C3=CC=CC=C3C2=O)=[CH:19][CH:18]=[C:17]([Cl:35])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2.CN>C(Cl)(Cl)Cl.CO>[NH2:24][CH2:23]/[CH:22]=[CH:21]/[C:20]1[C:2]([Cl:1])=[C:3]([C:17]([Cl:35])=[CH:18][CH:19]=1)[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2

참가 물질

5

반응물 2

HCID 6329MethylamineHCID 10601564HCID 10601564, 화합물

생성물 1

HCID 10643064HCID 10643064, 화합물수율 84.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6212Chloroform용매

실험 절차

To a solution of 8-[2,6-dichloro-3-((E)-3-phthalimido-1-propenyl)benzyloxy]-2-methylquinoline (43 mg) in chloroform (1 ml) was added 2M solution of methylamine in methanol (0.5 ml), and the mixture was stirred in the dark at ambient temperature overnight. The mixture was evaporated in vacuo, and the residue was purified by preparative thin layer chromatography to give 8-[3-((E)-3-amino-1-propenyl)-2,6-dichlorobenzyloxy]-2-methylquinoline (27 mg) as pale yellow amorphous.

후처리

  1. customThe mixture was evaporated in vacuo
  2. customthe residue was purified by preparative thin layer chromatography

출처 및 근거

ORD 기록
ord-d4e63b6e5ec44184bc96baf553054a13
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008229

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