4-Methylmorpholine → N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester

HRID 614203노트

반응식

HRID 614203 반응식
Cl.[CH2:2]([O:9][C:10](=[O:24])[C@H:11]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[NH:12][C:13](=[O:16])[CH2:14][NH2:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.ClC1C=C(Cl)C(Cl)=CC=1[O:34][C:35](=O)[CH2:36][NH:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39].CN1CCOCC1>C(Cl)Cl>[CH2:2]([O:9][C:10](=[O:24])[C@H:11]([CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[NH:12][C:13](=[O:16])[CH2:14][NH:15][C:35](=[O:34])[CH2:36][NH:37][C:38]([O:40][C:41]([CH3:43])([CH3:42])[CH3:44])=[O:39])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 79724-MethylmorpholineHCID 12799284t-Butoxycarbonylglycine-2,4,5-Trichlorophenyl EsterHCID 70603822glycyl-L-phenylalanine benzyl ester hydrochloride

생성물 1

HCID 54338339N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 6.1 parts glycyl-L-phenylalanine benzyl ester hydrochloride, 7.0 parts N-t-butoxycarbonylglycine 2,4,5-trichlorophenyl ester and 1.8 parts N-methylmorpholine in 150 parts methylene chloride is stirred overnight at room temperature. The solvents are then removed by evaporation under reduced pressure to yield the crude tripeptide. Purification by low pressure column chromatography affords pure N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester.

후처리

  1. customThe solvents are then removed by evaporation under reduced pressure
  2. customto yield the crude tripeptide
  3. customPurification by low pressure column chromatography

출처 및 근거

ORD 기록
ord-51e5c6e633014b468d7fc6b39a0ba378
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04144228

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