Isobutyryl chloride → N-[4-Bromo-3-(trifluoromethyl)phenyl]-2-methylpropanamide
반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[C:13](Cl)(=[O:17])[CH:14]([CH3:16])[CH3:15]>N1C=CC=CC=1>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]참가 물질
4
실험 절차
To a stirred, cooled solution of 15.0 g. of 4-bromo-3-trifluoromethylaniline in 75 ml. of dry pyridine add 6.8 g. of isobutyrylchloride and heat the resulting mixture at 70° C. for 2 hours. Allow the reaction mixture to cool to room temperature and then pour the mixture into 600 ml. of ice-water, filter and dry the precipitate which is recrystallized from 1:1 petroleum etherdichloromethane to yield 4'-bromo-3'-trifluoromethylisobutyranilide, m.p. 126.5°-128° C.
후처리
- temperatureTo a stirred, cooled solution of 15.0 g
- additionpour the mixture into 600 ml
- filtrationof ice-water, filter
- customdry the precipitate which
- customis recrystallized from 1:1 petroleum etherdichloromethane
출처 및 근거
- ORD 기록
- ord-7956379435e3441b9728625ae03f15b0
- 출처 데이터셋
- uspto-grants-1979_03
- 특허 번호
- US04144270
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