Butylamine → Hexadecanamide, N-butyl-

HRID 614305노트

반응식

HRID 614305 반응식
[C:1](Cl)(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[CH2:19]([NH2:23])[CH2:20][CH2:21][CH3:22]>C(OCC)C>[CH2:19]([NH:23][C:1](=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:20][CH2:21][CH3:22]

참가 물질

4

반응물 2

HCID 8007ButylamineHCID 8206Palmitoyl chloride

생성물 1

HCID 9972764Hexadecanamide, N-butyl-

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

An amount of 137.4 g of palmitoyl chloride in 100 ml of ethyl ether was added, under stirring at room temperature, to 80.5 g of n-butylamine in 700 ml of ethyl ether. Stirring was continued under gentle reflux for one hour. The precipitate was filtered off and thoroughly washed with water. The reaction product was recrystallized from ethanol giving 148.4 g of the title compound, melting point 74°-76° C.

후처리

  1. temperatureunder gentle reflux for one hour
  2. filtrationThe precipitate was filtered off
  3. washthoroughly washed with water
  4. customThe reaction product was recrystallized from ethanol giving 148.4 g of the title compound, melting point 74°-76° C.

출처 및 근거

ORD 기록
ord-414bb387c4ef4a389502d402939b919f
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04144320

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