HCID 22807221, 화합물 → HCID 70568628, 화합물

HRID 614556노트

반응식

HRID 614556 반응식
[O:1]=[C:2]1[N:8]2[C@H:4]([O:5][C:6]([CH:9]=[CH2:10])=[CH:7]2)[CH2:3]1.[H][H]>O1CCCC1.[Pt]>[CH:9](=[C:6]1[O:5][C@H:4]2[N:8]([C:2](=[O:1])[CH2:3]2)[CH2:7]1)[CH3:10]

참가 물질

5

반응물 2

HCID 22807221HCID 22807221, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 70568628HCID 70568628, 화합물수율 12%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8028Tetrahydrofuran용매

실험 절차

(5R)-7-oxo-3-vinyl-4-oxa-1-azabicyclo[3.2.0]hept-2-ene (2.4 mmole) in tetrahydrofuran (20 ml) was shaken with 5% platinum on charcoal (150 mg) under 1 atmosphere of hydrogen at room temperature for 1.5 hours. The catalyst was removed by filtration and was washed with tetrahydrofuran. The solvent was evaporated from the filtrate and the residue was chromatographed on silica gel using 1:7 ethyl acetate/petroleum ether (b.p. 60-80°). A mixture of E- and Z- isomers of the title compound was thus obtained as a colourless oil(40 mg).

후처리

  1. customThe catalyst was removed by filtration
  2. washwas washed with tetrahydrofuran
  3. customThe solvent was evaporated from the filtrate
  4. customthe residue was chromatographed on silica gel using 1:7 ethyl acetate/petroleum ether (b.p. 60-80°)
  5. additionA mixture of E- and Z- isomers of the title compound

출처 및 근거

ORD 기록
ord-09d6853dacce4eba84430dd25c410755
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04145430

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