Dichloromethane → 4-Acetoxy-2-naphthoic acid

HRID 614572노트

반응식

HRID 614572 반응식
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](C(O)=O)=[CH:4][CH:3]=1.C(Cl)Cl.[C:18](OC(=O)C)(=[O:20])[CH3:19].[C:25]([O:28]C(O)=O)(=[O:27])C>C(N(CC)CC)C.O1CCCC1>[C:18]([O:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([C:25]([OH:28])=[O:27])[CH:3]=1)(=[O:20])[CH3:19]

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 7918Acetic AnhydrideHCID 3442911-Hydroxy-4-naphthoic acidHCID 17769302Acetoxy carboxylic acid

생성물 1

HCID 200745924-Acetoxy-2-naphthoic acid

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8471Triethylamine용매

실험 절차

To a suspension of 2.3 g. of 4-hydroxy-1-naphthoic acid in 100 ml. of methylene chloride and 100 ml. of tetrahydrofuran, a mixture of 1.5 g. of triethylamine, 1.6 g. of 4-N-dimethylaminopyridine and 1.5 g. of acetic anhydride is added. The reaction mixture is heated at 50° for one hour. The solution is extracted with ethyl acetate, the organic layer washed with water and dilute hydrochloride acid and evaporated to dryness to yield 2.1 g. of the acetoxy carboxylic acid.

후처리

  1. additionTo a suspension of 2.3 g
  2. temperatureThe reaction mixture is heated at 50° for one hour
  3. extractionThe solution is extracted with ethyl acetate
  4. washthe organic layer washed with water and dilute hydrochloride acid
  5. customevaporated to dryness
  6. customto yield 2.1 g

출처 및 근거

ORD 기록
ord-d13c83f37c464df289808309d006fe33
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04145443

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