Hydrochloric Acid → 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

HRID 614677

반응식

HRID 614677 반응식
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][C:7]2[C:8](=[O:14])[NH:9][C:10](=S)[NH:11][CH:12]=2)=[CH:4][CH:3]=1.CC1C=CC(CC2C(=O)NC(SC)=NC=2)=CC=1.N1C=CC=NC1=O.[CH3:41][C:42]1[NH:46][CH:45]=[N:44][C:43]=1[CH2:47][S:48][CH2:49][CH2:50][NH2:51].[ClH:52]>>[ClH:52].[ClH:52].[CH3:41][C:42]1[NH:46][CH:45]=[N:44][C:43]=1[CH2:47][S:48][CH2:49][CH2:50][NH:51][C:10]1[NH:9][C:8](=[O:14])[C:7]([CH2:6][C:5]2[CH:15]=[CH:16][C:2]([CH3:1])=[CH:3][CH:4]=2)=[CH:12][N:11]=1

참가 물질

6

반응물 5

HCID 313Hydrochloric AcidHCID 684012(1H)-PyrimidinoneHCID 6655684-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 39393885-[(4-methylphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-oneHCID 129515095-(4-Methylbenzyl)-2-methylthio-4-pyrimidone

생성물 1

HCID 233461972-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

실험 절차

5-(4-Methylbenzyl)-2-thiouracil (4.65 g) was converted into 5-(4-methylbenzyl)-2-methylthio-4-pyrimidone (m.p. 208.5°-211° ex methanol/ethanol) by the method described in Example 1(i). Reaction of this pyrimidone (1.6 g) with 2-(5-methyl-4-imidazolylmethylthio)ethylamine (1.2 g) by the method described in Example 1(ii) and acidification with dilute ethanolic hydrogen chloride followed by evaporation to dryness and recrystallisation from ethanol gave 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride, m.p. 197°-198.5°.

후처리

  1. customfollowed by evaporation to dryness and recrystallisation from ethanol

출처 및 근거

ORD 기록
ord-9fff7e665fbc46da9cdd9d57e9a4e401
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04145546

연결된 노트

불러오는 중…