1-(3'-Nitro-phenyl)-2-formylamino-propane → 1-(3'-Aminophenyl)-2-formylamino-propane

HRID 614878노트

반응식

HRID 614878 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 213274321-(3'-Nitro-phenyl)-2-formylamino-propane

생성물 1

HCID 213274251-(3'-Aminophenyl)-2-formylamino-propane

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

5.2 gm of 1-(3'-nitro-phenyl)-2-formylamino-propane was hydrogenated in methanol in the presence of Raney nickel at atmospheric pressure and room temperature. Thereafeter, the catalyst was filtered off, the solvent was evaporated from the filtrate, and the residue was chromatographed on a silicagel column, using methanol/chloroform (2:8) as the flow agent. The eluate was evaporated, and the residue was recrystallized from ethyl acetate, yielding 1-(3'-amino-phenyl)- 2-formylamino-propane which had a melting point of 107°-108° C.

후처리

  1. filtrationThereafeter, the catalyst was filtered off
  2. customthe solvent was evaporated from the filtrate
  3. customthe residue was chromatographed on a silicagel column
  4. customThe eluate was evaporated
  5. customthe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-b6727f8875be4d9f93d65efb51c36fa2
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04146645

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