Hydroxyamine hydrochloride → 3,7-Dichloroquinoline-8-carbonitrile
반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13]Cl.Cl.[NH2:16]O.C([O-])=O.[Na+]>C(O)=O.O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[C:13]#[N:16]참가 물질
6
실험 절차
28.1 parts of 3,7-dichloro-8-chloromethylquinoline (Example 1), 6.95 parts of hydroxylamine hydrochloride and 13.6 parts of sodium formate in 200 ml of formic acid and 60 ml of water were stirred at 100° C. for 12 hours. The reaction solution was poured onto ice and the precipitated solid was filtered off with suction, washed neutral with water and dried. 19 parts of 3,7-dichloro-8-cyanoquinoline of melting point 222° C. were obtained. The yield corresponds to 78.5% of theory.
후처리
- additionThe reaction solution was poured onto ice
- filtrationthe precipitated solid was filtered off with suction
- washwashed neutral with water
- customdried
출처 및 근거
- ORD 기록
- ord-e484d41706ac45d68675df1294a7149d
- 출처 데이터셋
- uspto-grants-1985_02
- 특허 번호
- US04497651
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