Formamide → 3,7-Dichloro-8-formylaminomethylquinoline
반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13]Cl.[CH:15]([NH2:17])=[O:16]>O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13][NH:17][CH:15]=[O:16]참가 물질
4
실험 절차
24.6 parts of 3,7-dichloro-8-chloromethylquinoline (Example 1) in 300 parts of formamide were refluxed for 5 hours. Water was added and the solid was filtered off with suction and recrystallized from methanol. 23 parts of 3,7-dichloro-8-formylaminomethylquinoline of melting point 110° C. were obtained. The yield corresponds to 94% of theory.
후처리
- filtrationthe solid was filtered off with suction
- customrecrystallized from methanol
출처 및 근거
- ORD 기록
- ord-34994bb00d9f4ed78e4b0d34a151a011
- 출처 데이터셋
- uspto-grants-1985_02
- 특허 번호
- US04497651
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