Hydrochloric Acid → HCID 15580438, 화합물

HRID 615163노트

반응식

HRID 615163 반응식
Cl.O.C([NH:6][C:7]1[CH:24]=[CH:23][C:10]2[N:11]3[CH:16]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:14]=[C:12]3[S:13][C:9]=2[CH:8]=1)(=O)C>COCCO>[NH2:6][C:7]1[CH:24]=[CH:23][C:10]2[N:11]3[CH:16]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:14]=[C:12]3[S:13][C:9]=2[CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 70491659HCID 70491659, 화합물

생성물 1

HCID 15580438HCID 15580438, 화합물수율 83.1%

시약·촉매·용매 1

HCID 80192-Methoxyethanol용매

실험 절차

To a mixture of 100 ml of concentrated hydrochloric acid solution and 300 ml of methylcellosolve was added 8.5 g of 7-acetamido-2-phenylimidazo[2,1-b]benzothiazole mono-hydrate and the mixture was stirred for 4 hours at 100°-110° C. The reaction mixture was cooled to form crystals, which were recovered by filtration. The crystals were suspended in 200 ml of methylcellosolve and after alkalifying the suspension by adding concentrated aqueous ammonia, 80 ml of water was added to the mixture followed by cooling, thereby crystals precipitated. The crystals precipitated were recovered by filtration and dried to provide 5.76 g of 7-amino-2-phenylimidazo[2,1-b]benzothiazole.

후처리

  1. temperatureThe reaction mixture was cooled
  2. customto form crystals, which
  3. filtrationwere recovered by filtration
  4. additionby adding concentrated aqueous ammonia, 80 ml of water
  5. additionwas added to the mixture
  6. temperatureby cooling
  7. customcrystals precipitated
  8. customThe crystals precipitated
  9. filtrationwere recovered by filtration
  10. customdried

출처 및 근거

ORD 기록
ord-aeea73616b844914905167f9758f3f60
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04497817

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