1,2-Dibromoethane → 6-(2-Bromoethoxy)salicylamide
반응식
[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:3]=1[C:4]([NH2:6])=[O:5].C(=O)([O-])[O-].[K+].[K+].[Br:18][CH2:19][CH2:20]Br>C(#N)C>[Br:18][CH2:19][CH2:20][O:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:3]=1[C:4]([NH2:6])=[O:5]참가 물질
5
실험 절차
A mixture of 23.0 g of 2,6-dihydroxybenzamide, 20.7 g of potassium carbonate and 28.2 g of 1,2-dibromoethane is refluxed, whilst stirring, for 2-3 hours in 300 ml of acetonitrile. The reaction mixture is filtered whilst still warm, the filtrate concentrated by evaporation and the residue recrystallised from a little methanol. 6-(2-Bromoethoxy)salicylamide having a melting point of 120°-121° is obtained.
후처리
- temperatureis refluxed
- filtrationThe reaction mixture is filtered
- temperaturewhilst still warm
- concentrationthe filtrate concentrated by evaporation
- customthe residue recrystallised from a little methanol
출처 및 근거
- ORD 기록
- ord-47163b8fb6ae49a9b4394f743130485c
- 출처 데이터셋
- uspto-grants-1985_02
- 특허 번호
- US04497813
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