Chloroacetone → 2,3-dihydro-2,2-dimethyl-6-(2-oxopropoxy)-4H-1,3-benzoxazin-4-one

HRID 615241

반응식

HRID 615241 반응식
[CH3:1][C:2]1([CH3:14])[NH:7][C:6](=[O:8])[C:5]2[CH:9]=[C:10]([OH:13])[CH:11]=[CH:12][C:4]=2[O:3]1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:22][C:23](=[O:25])[CH3:24]>C(#N)C>[CH3:1][C:2]1([CH3:14])[NH:7][C:6](=[O:8])[C:5]2[CH:9]=[C:10]([O:13][CH2:22][C:23](=[O:25])[CH3:24])[CH:11]=[CH:12][C:4]=2[O:3]1

참가 물질

5

반응물 3

HCID 6571Chloroacetone2회HCID 11430Potassium CarbonateHCID 137543316-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1,3-benzoxazin-4-one

생성물 1

HCID 137543322,3-dihydro-2,2-dimethyl-6-(2-oxopropoxy)-4H-1,3-benzoxazin-4-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

70 g of 2,3-dihydro-2,2-dimethyl-6-hydroxy-4H-1,3-benzoxazin-4-one in 400 ml of acetonitrile with 100 g of potassium carbonate and 32 ml of chloroacetone are stirred under reflux for 30 hours. After the addition of a further 3.2 ml of chloroacetone, the reaction mixture is refluxed for a further 15-20 hours. The reaction mixture is filtered whilst still warm; the residue is thoroughly washed with acetone, and the combined filtrate is concentrated by evaporation. The crystalline residue is recrystallised from toluene and yields 2,3-dihydro-2,2-dimethyl-6-(2-oxopropoxy)-4H-1,3-benzoxazin-4-one, m.p. 125°-126°.

후처리

  1. temperatureunder reflux for 30 hours
  2. temperaturethe reaction mixture is refluxed for a further 15-20 hours
  3. filtrationThe reaction mixture is filtered
  4. temperaturewhilst still warm
  5. washthe residue is thoroughly washed with acetone
  6. concentrationthe combined filtrate is concentrated by evaporation
  7. customThe crystalline residue is recrystallised from toluene

출처 및 근거

ORD 기록
ord-ce006c809b9e4b24a79f84d254d6d71c
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04497813

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