Piperidine → [1-(2-Chlorophenyl)isoquinolin-3-yl](piperidin-1-yl)methanone

HRID 615390

반응식

HRID 615390 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([C:18](O)=[O:19])[N:9]=1.C(N(CC)CC)C.ClC(OCC)=O.[NH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([C:18]([N:34]2[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]2)=[O:19])[N:9]=1

참가 물질

6

반응물 4

HCID 8082PiperidineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 110005543-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)-

생성물 1

HCID 13272366[1-(2-Chlorophenyl)isoquinolin-3-yl](piperidin-1-yl)methanone수율 68.3%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Operations are carried out as for Example 7, starting with 1.42 g of 1-(2-chlorophenyl) isoquinoline 3-carboxylic acid, 0.58 g of triethylamine, 0.62 g of ethyl chloroformate and 0.55 g of piperidine in 50 ml of chloroform. 1.2 g of 1-[[1-(2-chlorophenyl) 3-isoquinolyl]carbonyl]piperidine, melting at 161° C. is obtained.

출처 및 근거

ORD 기록
ord-05cfd8a4714145f18052b43baff25812
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04499094

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