N-Methylcyclohexylamine → 1-(2-Chlorophenyl)-N-cyclohexyl-N-methylisoquinoline-3-carboxamide

HRID 615394

반응식

HRID 615394 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([C:18](O)=[O:19])[N:9]=1.C(N(CC)CC)C.ClC(OCC)=O.[CH3:34][NH:35][CH:36]1[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1>C(Cl)(Cl)Cl>[CH:36]1([N:35]([CH3:34])[C:18]([C:10]2[N:9]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:17]3[C:12]([CH:11]=2)=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:19])[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1

참가 물질

6

반응물 4

HCID 7514N-MethylcyclohexylamineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 110005543-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)-

생성물 1

HCID 132723721-(2-Chlorophenyl)-N-cyclohexyl-N-methylisoquinoline-3-carboxamide수율 64.8%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Operations are carried out as for Example 7, starting from 2.83 g of 1-(2-chloro phenyl) isoquinoline 3-carboxylic acid, 1.15 g of triethylamine, 1.24 g of ethyl chloroformate and 1.46 g of N-methyl cyclohexylamine in 100 ml of chloroform. 2.45 g of N-cyclohexyl N-methyl 1-(2-chloro phenyl) isoquinoline 3-carboxamide melting at 131° C., are obtained.

출처 및 근거

ORD 기록
ord-eaa46ff13785440fb25db1db329e3ed3
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04499094

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