Sodium Hydroxide → Pentiapine

HRID 615566

반응식

HRID 615566 반응식
[C:1]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1)(OCC)=O.[H-].[Li+].[OH-].[Na+]>O1CCCC1>[CH3:1][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 62714Lithium hydrideHCID 131782745-(4-Carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine

생성물 1

HCID 54742Pentiapine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To the solution of 0.2 g of 5-(4-carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine in 2 ml of dry tetrahydrofuran, 100 mg of lithium hydride are added at once and the mixture is refluxed under nitrogen for 48 hrs. The mixture is cooled to room temperature, stirred with 0.2 ml of pb 30% sodium hydroxide, and filtered. The filtrates were evaporated to dryness and the product is purified to give 5-(4-methylpiperazino]-imidazo[2,1-b][1,3,5]benzothiadiazepine, melting at 145°-147°, and identical to compound obtained in example 1.

후처리

  1. temperatureis refluxed under nitrogen for 48 hrs
  2. filtrationfiltered
  3. customThe filtrates were evaporated to dryness
  4. customthe product is purified

출처 및 근거

ORD 기록
ord-81d50e1b0f144953869aaeb0b436e3f3
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04500472

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