Hydrogen Bromide → 4-(1-Methylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

반응식

Cl.[CH3:2][N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[C:11]([O:17]C)[CH:10]=2)[CH2:4]1.[BrH:19]>>[BrH:19].[CH3:2][N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([OH:17])[CH:10]=2)[CH2:4]1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 203708493-(3,4-Dimethoxyphenyl)-1-methylpiperidine--hydrogen chloride (1/1)

생성물 1

HCID 30463704-(1-Methylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

실험 절차

A mixture of 8 g of the product of Step D in 40 ml of 66% hydrobromic acid was refluxed for an hour and then distilled to dryness under reduced pressure. The residue was dissolved in hot ethanol and the solution was cooled and vacuum filtered to obtain 2.49 g of N-methyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide as crystals melting at 190° C.

후처리

temperaturewas refluxed for an hour
distillationdistilled to dryness under reduced pressure
dissolutionThe residue was dissolved in hot ethanol
temperaturethe solution was cooled
filtrationvacuum filtered

출처 및 근거

ORD 기록: ord-e632f6c0e96542b191cc20acfbc3317c
출처 데이터셋: uspto-grants-1978_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04072685

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