Hydrogen Bromide → 4-(1-Ethylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

HRID 616030노트

반응식

HRID 616030 반응식
[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[C:11]([O:17]C)[CH:10]=2)[CH2:4]1)[CH3:2].[BrH:19]>>[BrH:19].[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([OH:17])[CH:10]=2)[CH2:4]1)[CH3:2]

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 203708473-(3,4-Dimethoxyphenyl)-1-ethylpiperidine

생성물 1

HCID 30463744-(1-Ethylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

실험 절차

A mixture of 5.9 g of N-ethyl-3-(3',4'-dimethoxyphenyl)-piperidine and 30 ml of 66% hydrobromic acid was refluxed for an hour and was then evaporated to dryness under reduced pressure. The residue was crystallized from ethanol to obtain 5.9 g of N-ethyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide melting at 207° C.

후처리

  1. temperaturewas refluxed for an hour
  2. customwas then evaporated to dryness under reduced pressure
  3. customThe residue was crystallized from ethanol

출처 및 근거

ORD 기록
ord-a8158c60499246db98d207962ae5c7c2
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04072685

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