1-Iodopropane → Piperidine, 3-(3,4-dimethoxyphenyl)-1-propyl-

HRID 616031노트

반응식

HRID 616031 반응식
[CH2:1](I)[CH2:2][CH3:3].[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:15]2[CH2:20][CH2:19][CH2:18][NH:17][CH2:16]2)[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]>C(Cl)(Cl)Cl.[Ag]=O>[CH2:1]([N:17]1[CH2:18][CH2:19][CH2:20][CH:15]([C:9]2[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[C:7]([O:6][CH3:5])[CH:8]=2)[CH2:16]1)[CH2:2][CH3:3]

참가 물질

5

반응물 2

HCID 336431-Iodopropane2회HCID 129379213-(3,4-Dimethoxyphenyl)piperidine

생성물 1

HCID 11300035Piperidine, 3-(3,4-dimethoxyphenyl)-1-propyl-

시약·촉매·용매 2

HCID 92152Silver(II) oxide촉매2회HCID 6212Chloroform용매

반응 조건

온도
20 °C

실험 절차

2 g of silver oxide and then 2 ml of propyl iodide were added to a solution of 4 g of 3-(3',4'-dimethoxyphenyl)-piperidine in 20 ml of chloroform and the mixture was stirred for 8 hours at 20° C under an inert atmosphere. Another 1 g of silver oxide and 1 ml of propyl iodide were added and the mixture was stirred for 15 hours. The mixture was filtered and the filtrate was evaporated to dryness. The residue was chromatographed over silica gel and eluted with a 6-3-1 cyclohexane-chloroform-triethylamine mixture to obtain 3.2 g of N-propyl-3-(3',4'-dimethoxyphenyl)-piperidine.

후처리

  1. stirringthe mixture was stirred for 15 hours
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated to dryness
  4. customThe residue was chromatographed over silica gel
  5. washeluted with a 6-3-1 cyclohexane-chloroform-triethylamine mixture

출처 및 근거

ORD 기록
ord-ace686240db543af8e6e1562059e4202
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04072685

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