Acetic Anhydride → HCID 3046378, 화합물

HRID 616037노트

반응식

HRID 616037 반응식
Br.[CH2:2]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([OH:18])[CH:12]=2)[CH2:6]1)[CH2:3][CH3:4].[C:19]([O-:22])(=O)[CH3:20].[Na+].[C:24](OC(=O)C)(=[O:26])[CH3:25]>>[CH2:2]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:24](=[O:26])[CH3:25])=[C:13]([O:18][C:19](=[O:22])[CH3:20])[CH:12]=2)[CH2:6]1)[CH2:3][CH3:4]

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 30463764-(1-Propylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

생성물 1

HCID 3046378HCID 3046378, 화합물

실험 절차

A suspension of 3.5 g of N-propyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide in 40 ml of acetic acid anhydride was stirred with 3.5 g of sodium acetate for 3 hours at 20° C and the mixture was then filtered. The filtrate was evaporated to dryness and the residue was taken up in a water-ethyl acetate mixture. The mixture was made alkaline with sodium bicarbonate addition and the organic phase was recovered by decanting. The organic phase was washed with water, dried and evaporated to dryness to obtain 3.3 g of N-propyl-3-(3',4'-diacetoxyphenyl)-piperidine.

후처리

  1. filtrationthe mixture was then filtered
  2. customThe filtrate was evaporated to dryness
  3. additionwith sodium bicarbonate addition
  4. customthe organic phase was recovered
  5. customby decanting
  6. washThe organic phase was washed with water
  7. customdried
  8. customevaporated to dryness

출처 및 근거

ORD 기록
ord-141b5958b6c347e685cbdb21ac8ed062
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04072685

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