Methanol → HCID 20371102, 화합물

HRID 616120노트

반응식

HRID 616120 반응식
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:12][CH:13]=[CH2:14])=[CH:7][C:6]=1[N+:15]([O-:17])=[O:16])(=O)C.CO.[OH-].[Na+]>O>[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:12][CH:13]=[CH2:14])=[CH:7][C:6]=1[N+:15]([O-:17])=[O:16]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 14273283N-{2-Nitro-4-[(prop-2-en-1-yl)sulfanyl]phenyl}acetamide

생성물 1

HCID 20371102HCID 20371102, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2 G. of 1-acetamido-2-nitro-4-(prop-2-en-1-ylthio)-benzene is treated with 20 ml. methanol and 10 ml. 5N aqueous sodium hydroxide at 20°-25° C for one hour. The mixture is diluted with water and the crude product filtered off. Recrystallization from benzene yields 1-amino-2-nitro-4-(prop-2-en-1-ylthio)benzene. This latter compound in 200 ml. acetone is treated with 4 g. methoxy carbonyl isothiocyanate at room temperatue for several days (i.e., until no starting material is present). The mixture is concentrated and the residue triturated with methanol to yield 1-(3-methoxycarbonyl-2-thioureido)-2-nitro-4-(prop-2-en-1-ylthio)benzene.

후처리

  1. filtrationthe crude product filtered off
  2. customRecrystallization from benzene

출처 및 근거

ORD 기록
ord-c6e7658458f34583b057d792ff7b6de9
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04072696

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