Benzyl mercaptan → 5-Benzylthiomethyl-2-oxo-cyclopentanecarboxylic acid methyl ester

HRID 616296

반응식

HRID 616296 반응식
CC(C)([O-:4])C.[K+].[CH2:7]([SH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:15][O:16][C:17]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[O:18]>>[CH3:15][O:16][C:17]([CH:19]1[CH:23]([CH2:24][S:14][CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:22][CH2:21][C:20]1=[O:4])=[O:18]

참가 물질

4

반응물 3

HCID 7509Benzyl mercaptanHCID 7826Methyl heptanoateHCID 23665647Potassium tert-butoxide

생성물 1

HCID 540315235-Benzylthiomethyl-2-oxo-cyclopentanecarboxylic acid methyl ester수율 78%

실험 절차

In accordance with the process of Example 16, potassium t-butoxide (336 mg; 3 m mol), benzyl mercaptan (372 mg; 3 m mol) and 2-oxo-bicyclo 3.1.0! hexane-1-carboxylic acid methyl ester (463 mg; 3 m mol) were used in the reaction, and the reaction product was purified by a silica gel column chromatography with ethyl acetate and n-hexane (1.5; 8.5) to obtain 650 mg of 5-benzylthiomethyl-2-oxo-cyclopentanecarboxylic acid methyl ester as an oil.

후처리

  1. customthe reaction product was purified by a silica gel column chromatography with ethyl acetate and n-hexane (1.5; 8.5)

출처 및 근거

ORD 기록
ord-9ddf21f58ffd4e66a86d7463b454d7de
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04073799

연결된 노트

불러오는 중…