Benzoyl chloride, 3-nitro- → 4,5-Dimethoxy-2-(3-nitrophenyl)aminobenzamide

HRID 61637

반응식

HRID 61637 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[N+:15]([C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)C(Cl)=O)([O-:17])=[O:16]>N1C=CC=CC=1>[CH3:12][O:11][C:9]1[C:8]([O:13][CH3:14])=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([NH:1][C:25]2[CH:24]=[CH:20][CH:19]=[C:18]([N+:15]([O-:17])=[O:16])[CH:26]=2)[CH:10]=1

참가 물질

4

반응물 2

HCID 8495Benzoyl chloride, 3-nitro-HCID 108672362-Amino-4,5-dimethoxybenzamide

생성물 1

HCID 668250984,5-Dimethoxy-2-(3-nitrophenyl)aminobenzamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a suspension of 2-amino-4,5-dimethoxybenzamide (5.05 g, 25.7 mmole) and 3-nitro benzoyl chloride (5.2 g, 28.0 mmole) CHCl3 (120 ml) was added pyridine (50 ml) drop wise at RT. The reaction mixture was stirred at RT for 24 h. The solvent was removed in vacuo and residue was triturated with Et2O, filtered and dried under high vacuum to give 4,5-dimethoxy-2-(3-nitrophenyl)aminobenzamide, which was used directly in the next step.

후처리

  1. customThe solvent was removed in vacuo and residue
  2. customwas triturated with Et2O
  3. filtrationfiltered
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-41cca07868b74e43a295ba5f4044bd66
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440961B2

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